Vulvar intraepithelial neoplasia, HPV-independent

**Definition:** Vulvar intraepithelial neoplasia (VIN), HPV-independent, is a non-invasive precursor of HPV-independent squamous cell carcinoma of the vulva, characterized by atypia of the basal and parabasal keratinocytes in an otherwise well-differentiated epithelium.

**Exclusions:** - Low grade squamous intraepithelial lesion of vulva