Major osseous defect

**Code first:** - underlying disease, if known, such as: - aseptic necrosis of bone (M87.-) - malignant neoplasm of bone (C40.-) - osteolysis (M89.5-) - osteomyelitis (M86.-) - osteonecrosis (M87.-) - osteoporosis (M80.-, M81.-) - periprosthetic osteolysis (T84.05-)