Thyrotoxicosis with diffuse goitre

**Definition:** Thyrotoxicosis with diffuse goitre (also known as Graves disease or Basedow disease) is a form of autoimmune thyroid disease and is the leading cause of hyperthyroidism and thyrotoxicosis. In this condition, thyroid-stimulating immunoglobulins bind to and activate the TSH receptor, resulting in excessive thyroid hormone production. The disease is characterized by goiter, rapid and irregular heartbeat, weight loss, irritability, anxiety, and often a (slight) protrusion of the eyeballs.

**Inclusions:** - Graves disease - toxic diffuse goitre