Ventricular septal defect as current complication following acute myocardial infarction

**Definition:** A mechanical rupture of the interventricular septum after ST elevation myocardial infarction resulting in the left-to-right shunt to deteriorate hemodynamic, which confers a high 30-day mortality. Rupture of the septum with an anterior infarction tends to be apical in location, whereas inferior infarctions are associated with perforation of the basal septum.