Non-alcoholic fatty liver disease

**Definition:** NAFLD is characterised by fatty liver related to insulin resistance in the absence of significant alcohol consumption. It embraces a pathological spectrum from simple steatosis to steatohepatitis. 10-20% of cases have steatohepatitis (non-alcoholic steatohepatitis: NASH), which can progress to cirrhosis and hepatocellular carcinoma.

**Exclusions:** - inherited defects in mitochondrial metabolism - Reye syndrome - Acute fatty liver of pregnancy - Drug-induced or toxic liver disease - Chronic hepatitis C - Alcoholic liver disease