Ovarian hyperstimulation syndrome

**Definition:** A disease of the endocrine system, caused by elevated human chorionic gonadotropin hormone, commonly after the use of injectable fertility treatments. This disease is characterised by ovarian enlargement, and hemodynamic or metabolic complications. This disease may also present with abdominal pain, abdominal bloating, or weight gain depending on graded symptoms.

**Long definition:** an exaggerated systemic response to ovarian stimulation characterized by a wide spectrum of clinical and laboratory manifestations. It is classified as mild, moderate or severe according to the degree of abdominal distention, ovarian enlargement and respiratory, hemodynamic and metabolic complications. Mild: Mild abdominal discomfort with ovaries less than 5 cm and no medical intervention other than observation and ""pelvic rest"" are required. Moderate: Moderate abdominal discomfort and or other symptoms of ascites, no hemoconcentation (Hct < 45) with either ovary between 5-10 cm in size. Severe: Severe abdominal discomfort and/or other symptoms of ascites, hemoconcentration (Hct >45) and/or other serious biochemical abnormalities requiring hospitalization for observation and/or for medical intervention (paracentesis, detorsion, other,....)".

**Inclusions:** - Hyperstimulation of ovaries associated with induced ovulation