Ataxin-3

**Definition:** A deubiquitinating enzyme of the ATAXINS family. It functions in protein homeostasis, GENETIC TRANSCRIPTION; CYTOSKELETON regulation, and MYOGENESIS. CAG TRINUCLEOTIDE REPEAT EXPANSION in the Ataxin-3 gene coding region is associated with spinocerebellar ataxia-3 (MACHADO-JOSEPH DISEASE).

**Tree numbers:** - D08.811.037.250 - D12.776.631.069.875 - D12.776.660.075.875

**Synonyms:** - Spinocerebellar Ataxia 3 Protein - ATXN3 Protein - Ataxin-3 Protein - Machado-Joseph Disease Protein - SCA3 Protein