Pemetrexed

**Definition:** A guanine-derived ANTINEOPLASTIC AGENT that functions as a NUCLEIC ACID SYNTHESIS INHIBITOR through its binding to, and inhibition of, THYMIDYLATE SYNTHASE.

**Tree numbers:** - D03.633.100.759.758.399.454.650 - D12.125.067.625.525 - D12.125.119.409.525

**Synonyms:** - MTA - N-(4-(2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid