Imatinib Mesylate

**Definition:** A tyrosine kinase inhibitor and ANTINEOPLASTIC AGENT that inhibits the BCR-ABL kinase created by chromosome rearrangements in CHRONIC MYELOID LEUKEMIA and ACUTE LYMPHOBLASTIC LEUKEMIA, as well as PDG-derived tyrosine kinases that are overexpressed in gastrointestinal stromal tumors.

**Tree numbers:** - D02.065.277.456 - D02.241.223.100.100.435 - D02.455.426.559.389.127.085.465 - D03.383.606.405 - D03.383.742.349

**Synonyms:** - Imatinib Methanesulfonate