Type II Secretion Systems

**Definition:** Gram-negative bacterial secretion systems which carry out the secretion of folded proteins.T2SSs secrete folded proteins from the PERIPLASMIC SPACE that have been exported there by SEC TRANSLOCASE or TAT SECRETION SYSTEMS, or they secrete folded proteins directly from the CYTOPLASM. The T2SSs have four substructures, an ATPase, an inner membrane platform, a pseudopilin, and secretin, an outer membrane complex which is a channel for secretion. (This bacterial secretin is not the same as the mammalian hormone also named SECRETIN.)

**Tree numbers:** - D05.500.890.500.750

**Synonyms:** - Type 2 Secretion System - Type II Secretion System - Type 2 Secretion Systems - Bacterial Secretion System, Type II - T2SS Secretion System