Natalizumab

**Definition:** A humanized monoclonal immunoglobulin G4 antibody to human INTEGRIN ALPHA4 that binds to the alpha4 subunit of INTEGRIN ALPHA4BETA1 and integrin alpha4beta7. It is used as an IMMUNOLOGIC FACTOR in the treatment of RELAPSING-REMITTING MULTIPLE SCLEROSIS and CROHN'S DISEASE.

**Tree numbers:** - D12.776.124.486.485.114.224.060.813 - D12.776.124.790.651.114.224.060.813 - D12.776.377.715.548.114.224.200.813