Discoidin Domain Receptors

**Definition:** Receptor tyrosine kinases that bind COLLAGENS. They are characterized by the presence of extracellular DISCOIDIN DOMAINS that activate SIGNAL TRANSDUCTION PATHWAYS in response to collagen binding. They may also be cleaved by MATRIX METALLOPROTEINASES to mediate cell interactions with the EXTRACELLULAR MATRIX.

**Tree numbers:** - D08.811.913.696.620.682.725.400.005 - D12.776.476.568.400.005 - D12.776.543.750.630.005 - D12.776.543.750.685.050 - D12.776.543.750.705.880.300

**Synonyms:** - Discoidin Domain Receptor - DDR Proteins