Mismatch Repair Endonuclease PMS2

**Definition:** A MutL protein and component of the DNA MISMATCH REPAIR system. Its ENDONUCLEASE activity introduces SINGLE-STRAND DNA BREAKS which create entry points for EXO1 exonuclease to remove the strand containing the mismatch. It may also function in DNA DAMAGE signaling.

**Tree numbers:** - D08.811.074.766.250 - D08.811.277.040.025.215.250 - D08.811.277.352.335.350.600 - D12.776.260.540.250

**Synonyms:** - PMS2 Protein - Postmeiotic Segregation Increased-S. cerevisiae-2 - PMS1 Homolog 2, Mismatch Repair Protein - PMS-2 Protein