Beclin-1

**Definition:** An autophagy related protein which functions as a core subunit of PHOSPHATIDYLINOSITOL 3-KINASE MULTIPROTEIN COMPLEXES. It mediates the formation of phosphatidylinositol 3-phosphate and functions in AUTOPHAGY, where it is required for maturation of the AUTOPHAGOSOME. It also functions in ENDOCYTOSIS and CYTOKINESIS as part of a separate complex. Beclin-1 associates with INTRACELLULAR MEMBRANES and interacts with the PROTO-ONCOGENE PROTEINS C-BCL-2 and BCL-X PROTEIN.

**Tree numbers:** - D12.644.360.075.335 - D12.776.094.500 - D12.776.476.075.335

**Synonyms:** - Beclin-1 Protein - ATG6 Protein - ATG-6 Protein - Coiled-coil Myosin-like Bcl2-interacting Protein - GT197 Protein - Beclin1