Autophagy-Related Protein 5

**Definition:** An autophagy-related protein that functions in AUTOPHAGOSOME biogenesis. It is conjugated to the ATG12 PROTEIN via a process that is similar to UBIQUITINATION and involves the ATG7 PROTEIN and ATG10 enzyme. The ATG12-ATG5 conjugate acts as an E3 UBIQUITIN LIGASE-like enzyme and is required for the localization of ATG8 PROTEINS to AUTOPHAGOSOME vesicle membranes and modification of membrane lipids.

**Tree numbers:** - D12.776.094.250

**Synonyms:** - Autophagy Protein-5 - Autophagy-Related 5 Protein - ATG5 Protein - ATG-5 Protein - Apoptosis-Specific Protein