Carbonic Anhydrase IX

**Definition:** A carbonic anhydrase and transmembrane protein that consists of an N-terminal PROTEOGLYCAN-like domain, a catalytic region, a single-pass transmembrane domain, and a short intracellular tail. It functions as a dimer and is expressed primarily by cells of the GASTROINTESTINAL TRACT; BILE DUCT EPITHELIUM; and GALL BLADDER. It is expressed at high levels in many solid tumors, especially CLEAR CELL RENAL CARCINOMA, in response to CELL HYPOXIA.

**Tree numbers:** - D08.811.520.241.300.150.450 - D12.776.543.178 - D23.050.285.196

**Synonyms:** - Carbonic Anhydrase 9 - CAIX Protein