Forkhead Box Protein O3

**Definition:** A forkhead box transcription factor and transcriptional activator which triggers type 1 programmed cell death (APOPTOSIS) in the absence of APOPTOSIS INHIBITING PROTEINS, including neuronal cell death induced by OXIDATIVE STRESS. It recognizes and binds to the DNA sequence 5'-(AG)TAAA(TC)A-3' and also functions in post-transcriptional regulation of the c-MYC PROTO-ONCOGENE.

**Tree numbers:** - D12.776.260.950.249.125 - D12.776.930.977.249.125

**Synonyms:** - Forkhead in Rhabdomyosarcoma-Like 1 Protein - FOXO3 Protein