ETS Motif

**Definition:** A helix-turn-helix motif characterized by three alpha-helices and four-stranded beta-sheets arranged in the order alpha1-beta1-beta2-alpha2-alpha3-beta3-beta4. The third alpha-helix contacts the major groove of DNA. The ETS motif and the flanking amino acid sequences of Ets proteins influence the binding affinity, and the alteration of a single amino acid in the Ets domain can change its DNA binding specificity.

**Tree numbers:** - G02.111.570.820.709.275.500.360.360.500

**Synonyms:** - ETS Domain - Helix-Turn-Helix, ETS-Type Domain Containing