Src Homology 2 Domain-Containing, Transforming Protein 1

**Definition:** An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION.

**Tree numbers:** - D12.644.360.024.330.500 - D12.776.157.057.162.500 - D12.776.476.024.424.500

**Synonyms:** - SHC (Src Homology 2 Domain-Containing) Transforming Protein 1 - SHC1 (Src Homology 2 Domain-Containing) Protein - Src Homology 2 Domain-Containing-Transforming Protein C1 - ShcA Protein - SHC-Transforming Protein 1 - SHC1 Protein