N-Myc Proto-Oncogene Protein

**Definition:** A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. In mammals, it is highly expressed in the brain during embryogenesis and is essential for brain development; it is not expressed in adult tissues. Amplification or overexpression of N-Myc occurs in at least 20% of tumors and is associated with a poor prognosis in cases of NEUROBLASTOMA; ALVEOLAR RHABDOMYOSARCOMA; SMALL CELL LUNG CARCINOMA; and neuroendocrine prostate cancer.

**Tree numbers:** - D12.776.260.103.500.625 - D12.776.260.108.092.625 - D12.776.624.664.700.158 - D12.776.930.125.500.563 - D12.776.930.127.092.625

**Synonyms:** - N-Myc Protein - MYCN Protein - NMYC Protein - Class E Basic Helix-Loop-Helix Protein 37 - BHLHE37 Protein