Sequestosome-1 Protein

**Definition:** A multidomain protein that is highly conserved among multicellular organisms. It contains a ZZ-type ZINC FINGER domain, C-terminal UBIQUITIN - associated (UBA) domain, and interacts with many other signaling proteins and enzymes including, atypical PROTEIN KINASE C; TNF RECEPTOR-ASSOCIATED FACTOR 6; subunits of the mTORC1 complex, and CASPASE-8. It functions in AUTOPHAGY as a receptor for the degradation of ubiquitinated substrates, and to co-ordinate signaling in response to OXIDATIVE STRESS.

**Tree numbers:** - D12.644.360.024.329 - D12.776.094.750 - D12.776.157.057.160 - D12.776.476.024.422

**Synonyms:** - EBI3-Associated Protein of 60 KDa - EBIAP Protein - Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 Kda - Ubiquitin-Binding Protein p62