DEAD Box Protein 58

**Definition:** A DEAD-box RNA helicase that contains an N-terminal DEATH-LIKE DOMAIN, AAA+ ATPase domain, and C-terminal RNA HELICASE activity. It functions as an innate immune receptor through its recognition of viral nucleic acids. It also induces the expression of INTERFERON TYPE I and proinflammatory CYTOKINES. Its ligands include: 5'-triphosphorylated SINGLE-STRANDED RNA, DOUBLE-STRANDED RNA (dsRNA), and short dsRNA (less than 1 kb in length).

**Tree numbers:** - D08.811.913.696.445.735.720.249.750

**Synonyms:** - RIG-I-like Receptor 1 - DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 - Probable ATP-Dependent RNA Helicase DDX58