AlkB Homolog 4, Lysine Demethylase

**Definition:** A dioxygenase and alkylation repair homolog that mediates demethylation of ACTIN monomethylated at 'Lys-84' (K84me1). Demethylation of actin LYSINE 84 (K84me1) is required for maintaining actin and MYOSIN dynamics to support normal cleavage furrow ingression during CYTOKINESIS and CELL MIGRATION. It may also be involved in transcription regulation.

**Tree numbers:** - D08.811.682.662.582.138 - D08.811.682.690.416.139.937

**Synonyms:** - Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 4 - Alkylated DNA Repair Protein AlkB Homolog 4