AlkB Homolog 8, tRNA Methyltransferase

**Definition:** A dioxygenase and alkylation repair homolog that catalyzes the methylation of 5-carboxymethyl URIDINE to 5-methylcarboxymethyl uridine at the wobble position of the ANTICODON loop in TRANSFER RNA (tRNA) via its methyltransferase domain. It has a preference for tRNA (ARGININE) and tRNA (GLUTAMATE), and does not bind tRNA (LYSINE).

**Tree numbers:** - D08.811.682.690.416.139.984 - D08.811.913.555.500.925.500

**Synonyms:** - Alkylated DNA Repair Protein Alkb Homolog 8 - Probable Alpha-Ketoglutarate-Dependent Dioxygenase ABH8 - S-Adenosyl-L-Methionine-Dependent tRNA Methyltransferase ABH8 - tRNA (Carboxymethyluridine(34)-5-O)-Methyltransferase ABH8