Alpha-Ketoglutarate-Dependent Dioxygenase FTO

**Definition:** A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS.

**Tree numbers:** - D08.811.074.062.968 - D08.811.682.662.582.242 - D08.811.682.690.416.139.992

**Synonyms:** - Alpha-Ketoglutarate-Dependent Dioxygenase - Fat Mass and Obesity Associated (FTO) Protein - Fat Mass and Obesity Associated Protein - AlkB Homolog 9 Protein