beta-Arrestins

**Definition:** Non-visual system arrestins that negatively regulate G-PROTEIN-COUPLED RECEPTORS (GPCRs) and may also function independently of GPCR signaling. They bind and recruit many different signaling factors, including MITOGEN-ACTIVATED PROTEIN KINASES; SRC-FAMILY-KINASES; and FILAMIN to GPCRs and may recognize different phosphorylation states of the receptors to determine the specificity of the cellular response to signaling.

**Tree numbers:** - D12.644.360.024.098.525 - D12.776.157.057.005.525 - D12.776.476.024.104.525 - D12.776.543.090.525

**Synonyms:** - beta-Arrestin