Histidine Kinase

**Definition:** A member of the transferase superfamily of proteins. In the activated state, protein-histidine kinase autophosphorylates at a histidine residue, subsequently transferring high-energy phosphoryl groups to an aspartate residue of the response-regulator domain, which results in a conformational shift in the effector domain. Histidine kinases mediate signal transduction in a wide range of processes involving cellular adaptation to environmental stress.

**Tree numbers:** - D08.811.913.696.620.682.424

**Synonyms:** - Protein-Histidine Kinase - Histidine Protein Kinase