Soluble Guanylyl Cyclase

**Definition:** A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals.

**Tree numbers:** - D08.811.520.650.600.750 - D12.776.476.350.500

**Synonyms:** - Nitric Oxide Receptor - Nitric Oxide Receptors - Nitric Oxide-Sensitive Guanylyl Cyclase - Receptor, Nitric Oxide - Soluble Guanylate Cyclase