BTB-POZ Domain

**Definition:** A homodimerization protein interaction domain occurring at the N terminus of proteins that contain multiple copies of either CYS2-HIS2 ZINC FINGERS or KELCH REPEATS. It is characterized by a tightly intertwined dimer with an extensive hydrophobic interface. A surface-exposed groove lined with conserved amino acids is formed at the dimer interface, suggesting a peptide-binding site. Many BTB proteins are transcriptional regulators that are thought to regulate CHROMATIN structure.

**Tree numbers:** - G02.111.570.820.709.275.750.500.343

**Synonyms:** - BTB Domain - POZ Domain - BTB (POZ) Domain - Broad-Complex, Tramtrack and Bric a Brac Domain - POxvirus and Zinc Finger Domain