Tumor Suppressor p53-Binding Protein 1

**Definition:** A nuclear and cytoplasmic protein that associates with KINETOCHORES and contains a C-terminal TUDOR DOMAIN. It plays a critical role in the cellular response to DNA DAMAGE and localizes to DOUBLE-STRAND DNA BREAKS. It may also function in M PHASE CELL CYCLE CHECKPOINTS and as an enhancer of TUMOR SUPPRESSOR PROTEIN P53-mediated transcriptional activation.

**Tree numbers:** - D12.776.260.805 - D12.776.660.235.850 - D12.776.664.235.950

**Synonyms:** - Tumor Protein p53-Binding Protein, 1 - 53BP1 Protein - p202 Protein - TP53BP1 Protein