Checkpoint Kinase 1

**Definition:** A serine/threonine-specific protein kinase which is encoded by the CHEK1 gene in humans. Checkpoint kinase 1 (also known as Chk1) coordinates DNA damage response and cell cycle checkpoint response. Under these conditions, activation of Chk1 results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death, to prevent damaged cells from progressing through the cell cycle.

**Tree numbers:** - D08.811.913.696.620.682.700.143 - D12.776.476.563.143

**Synonyms:** - Checkpoint-1 Kinase - Chk1 Kinase - Chk1 Protein Kinase