Transcription Factor HES-1

**Definition:** A basic-helix-loop-helix transcription factor that functions as a transcriptional repressor for genes transcribed by bHLH proteins. For example, it may negatively regulate MYOGENESIS by inhibiting MyoD1 and ASH1 proteins. It is also required for the stability of FANCONI ANEMIA COMPLEMENTATION GROUP PROTEINS and their localization to the cell nucleus in response to DNA DAMAGE.

**Tree numbers:** - D12.776.260.103.844 - D12.776.930.125.844

**Synonyms:** - Hairy and Enhancer of Split 1 Protein - Hairy-Like Transcription Factor