Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases

**Definition:** Phosphoinositide phosphatases that catalyze the dephosphorylation (hydrolysis) of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), which negatively regulates the PI3K ( 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES) pathways. They contain an SH2 DOMAIN and STERILE ALPHA MOTIF and have important functions in regulating the immune response and other cellular processes in vertebrates.

**Tree numbers:** - D08.811.277.352.650.624.750

**Synonyms:** - SHIP Phosphatases - Src Homology 2 Domain-Containing Inositol Phosphatases