ADAM17 Protein

**Definition:** A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. It cleaves several other CELL SURFACE PROTEINS, including INTERLEUKIN-1 RECEPTOR TYPE II; TRANSFORMING GROWTH FACTOR ALPHA; L-SELECTIN; MUCIN-1; and AMYLOID BETA-PROTEIN PRECURSOR. It can also function as an activator of the Notch signaling pathway by mediating the cleavage of NOTCH RECEPTORS.

**Tree numbers:** - D08.811.277.656.675.374.102.375 - D09.400.430.500.375 - D12.776.395.033.375

**Synonyms:** - TACA (Enzyme) - TACE (Enzyme) - TNF-alpha Converting Enzyme - Tumor Necrosis Factor Alpha Convertase - Tumor Necrosis Factor-alpha Convertase - Tumor Necrosis Factor-alpha Converting Enzyme - TNF-alpha Convertase - CD156b Antigen - ADAM-17 Protein - Disintegrin and Metalloproteinase Domain-Containing Protein 17 - ADAM-17