ERG1 Potassium Channel

**Definition:** One of three members of the ether-a-go-go (EAG) POTASSIUM CHANNELS gene family comprising ether-a-go-go (eag), eag-like (elk) and eag-related (erg) subfamilies. Ether-a-go-go-related gene 1 (ERG1) also known as KCNH2, encodes the pore-forming subunit of a rapidly activating-delayed rectifier potassium channel that plays an essential role in the final repolarization of ventricular action potential. Loss-of-function mutations in human hERG1 is associated with life-threatening ARRHYTHMIA.

**Tree numbers:** - D12.776.157.530.400.600.900.249.500 - D12.776.543.550.450.750.900.249.500 - D12.776.543.585.400.750.900.249.500

**Synonyms:** - Ether-A-Go-Go-Related Potassium Channel 1 - Potassium Voltage-Gated Channel, Subfamily H, Member 2