Dishevelled Proteins

**Definition:** A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY.

**Tree numbers:** - D12.644.360.024.288 - D12.776.157.057.028 - D12.776.476.024.330

**Synonyms:** - Dishevelled Protein