Interferon-Induced Helicase, IFIH1

**Definition:** A DEAD box RNA helicase that contains two N-terminal CASPASE ACTIVATION AND RECRUITMENT DOMAINS. It functions as a sensor of viral NUCLEIC ACIDS such as DOUBLE-STRANDED RNA and activates the INNATE IMMUNE RESPONSE by inducing the expression of INTERFERON-ALPHA and INTERFERON-BETA. It may also regulate cell growth and APOPTOSIS.

**Tree numbers:** - D08.811.913.696.445.735.720.249.875 - D12.776.066.125

**Synonyms:** - Interferon-Induced Helicase C Domain-Containing Protein 1 - Melanoma Differentiation-Associated Protein 5 - IFIH1 Protein - CADM-140 Autoantigen - Interferon Induced with Helicase C Domain 1 - Helicard