Triggering Receptor Expressed on Myeloid Cells-1

**Definition:** An approximately 230 amino acid membrane glycoprotein characterized by an IMMUNOGLOBULIN V-SET DOMAIN in its N-terminal half. It is expressed by MONOCYTES and NEUTROPHILS in response to INFLAMMATION related to bacterial and fungal infections. It triggers the release of pro-inflammatory CHEMOKINES; CYTOKINES, and expression of cell activation markers and is a critical regulator of SEPTIC SHOCK.

**Tree numbers:** - D09.400.430.890.919 - D12.776.395.550.919 - D12.776.543.550.919 - D12.776.543.750.705.985

**Synonyms:** - CD354 Antigen - TREM-1 Protein