Transcription Factor 4

**Definition:** A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder.

**Tree numbers:** - D12.776.260.108.092.937 - D12.776.930.125.500.937

**Synonyms:** - TCF-4 Protein - TCF4 Transcription Factor - TCF-4 Transcription Factor