T-Cell Intracellular Antigen-1

**Definition:** An RNA-binding protein characterized by three RNA RECOGNITION MOTIFS. It binds to AU RICH ELEMENTS in the 3'-untranslated regions of mRNA and regulates alternative pre-RNA splicing and mRNA translation; it may also function in APOPTOSIS. Mutations in the TIA-1 gene are associated with WELANDER DISTAL MYOPATHY.

**Tree numbers:** - D12.776.157.725.452.750 - D12.776.157.725.813.937 - D12.776.157.725.829.875 - D12.776.664.962.452.750 - D12.776.664.962.813.937 - D12.776.664.962.829.875

**Synonyms:** - RNA-Binding Protein TIA-1 - T-Cell-Restricted Intracellular Antigen-1