Protein Kinase C-theta

**Definition:** A calcium-independent, phospholipid- and diacylglycerol-dependent, protein kinase C subtype that contains an N-terminal C2 DOMAIN and two diacylglycerol-binding ZINC FINGERS. It is expressed primarily by T-LYMPHOCYTES and localizes to IMMUNOLOGICAL SYNAPSES where it regulates downstream signaling for the activation, proliferation, and survival of mature T-cells. It plays a critical role in allergic, autoimmune, and alloimmune responses of TH2 CELLS and TH17 CELLS.

**Tree numbers:** - D08.811.913.696.620.682.700.725.075 - D12.776.476.563.725.075

**Synonyms:** - Protein Kinase C theta - Protein Kinase C, theta - PKC-theta - PRKCQ