Kazal Motifs

**Definition:** Highly conserved protein domains characteristic of SERINE PROTEASE INHIBITORS, KAZAL TYPE. They generally occur as tandem repeats, with each domain consisting of approximately 60 amino acids that form a large extended amino acid chain, two short ALPHA-HELICES, and a three-stranded anti-parallel BETA-SHEET. Kazal-like domains also occur in the extracellular portions of AGRIN.

**Tree numbers:** - G02.111.570.820.709.275.500.490

**Synonyms:** - Kazal Domains - Kazal Domain - Kazal Motif