Serine Peptidase Inhibitor Kazal-Type 5

**Definition:** A secreted serine peptidase inhibitor that consists of 15 KAZAL MOTIFS and inhibits KALLIKREINS KLK5, KLK7, and KLK14 as well as TRYPSIN. It plays important roles in protecting MUCOSA against infection and inflammation, and in maintaining the integrity of the skin. Mutations in the SPINK5 gene are associated with NETHERTON SYNDROME.

**Tree numbers:** - D12.644.822.750.250 - D12.776.815.688.250

**Synonyms:** - Serine Protease Inhibitor Kazal-Type 5 - Lympho-Epithelial Kazal-Type Inhibitor - SPINK5 Protein - LEKTI Protein