Zinc Finger E-box Binding Homeobox 2

**Definition:** A transcription factor that consists of 8 CYS2-HIS2 ZINC FINGERS flanking a central HOMEOBOX. It binds to the 5'-CACCT-3' DNA sequence located within E-BOX ELEMENTS of many genes essential for embryonic growth and development and regulates their activity; it represses transcription of the E-CADHERIN gene. Mutations in the ZEB2 gene are associated with MOWAT-WILSON SYNDROME.

**Tree numbers:** - D12.776.260.400.883 - D12.776.260.703.700 - D12.776.930.780.918

**Synonyms:** - Zeb2 Transcription Factor - Smad-Interacting Protein 1 - Zinc Finger E-box Binding Homeobox 2 Protein