Zinc Finger Protein Gli3

**Definition:** A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES.

**Tree numbers:** - D12.776.260.522.875 - D12.776.260.703.900 - D12.776.930.375.875 - D12.776.930.780.972

**Synonyms:** - GLI-Kruppel Family Member 3 Protein - Glioma-Associated Oncogene Family Zinc Finger 3 Protein