Valosin Containing Protein

**Definition:** A highly-conserved AAA ATPase that functions in the biogenesis of the transitional ENDOPLASMIC RETICULUM and fragmentation and reassembly of the GOLGI APPARATUS during MITOSIS. It also functions in a complex with UFD1L and NPLOC4 proteins to export misfolded ubiquitinated proteins from the endoplasmic reticulum and outer mitochondrial membrane to the cytoplasm for degradation by the PROTEASOME and also plays a role in AUTOPHAGY of ubiquitinated proteins. It occurs in neuronal INCLUSION BODIES from patients with AMYOTROPHIC LATERAL SCLEROSIS and LEWY BODIES from PARKINSON DISEASE patients.

**Tree numbers:** - D08.811.277.040.013.500.750 - D08.811.277.040.025.024.750 - D12.776.157.025.750.750 - D12.776.167.800

**Synonyms:** - CDC48 Protein - Valosine-Containing Protein - Cell Cycle Protein CDC48p - p97 Valosin-Containing Protein - Valosin-Containing Protein - Cell Cycle Protein CDC48