Lysine Acetyltransferase 5

**Definition:** A catalytic subunit of the NuA4 histone acetyltransferase complex that functions in transcriptional activation of genes by acetylation of nucleosomal HISTONES H4 and H2A, altering nucleosome-DNA interactions and interaction of the modified histones with other activating transcription factors. It may control gene expression changes associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest; CELL AGING; APOPTOSIS; and DNA REPAIR. It is polyubiquitinated and degraded during HIV-1 infection through its interaction with the viral TAT PROTEIN.

**Tree numbers:** - D08.811.913.050.134.415.500.062

**Synonyms:** - HTATIP - KAT5 (TIP60) Protein - HIV-1-Tat Interactive Protein Tip60