Positive Regulatory Domain I-Binding Factor 1

**Definition:** A transcriptional repressor protein that contains an N-terminal PR-SET domain, four C-terminal CYS2-HIS2 ZINC FINGERS, and binds the PRDI element in the INTERFERON-BETA gene. It has methyltransferase activity and mediates gene transcription in tissue-specific innate and adaptive immune lymphocyte T-CELLS, repressing expression of proteins that promote exit of these tissue-specific T-cell populations from non-lymphoid organs.

**Tree numbers:** - D08.811.913.555.500.800.700 - D12.776.260.703.650 - D12.776.930.780.904

**Synonyms:** - PRDM1 Protein - BLIMP1 Protein - B Lymphocyte-Induced Maturation Protein 1 - PRDI-BF1 Protein