Deubiquitinating Enzyme CYLD

**Definition:** A deubiquitinase and tumor-suppressor protein that specifically cleaves LYSINE-63-linked polyubiquitin chains and also has endodeubiquitinase activity. It functions to regulate NF-KAPPA B and WNT SIGNALING PATHWAY activity, contributing to cell survival, proliferation, and differentiation. Mutations in the CYLD gene are associated with cases of FAMILIAL CYLINDROMATOSIS.

**Tree numbers:** - D08.811.037.375 - D12.776.624.776.482

**Synonyms:** - CYLD Protein - Cylindromatosis Protein - Deubiquitinating Enzyme Cylindromatosis