Abuse-Deterrent Formulations

**Definition:** Drug formulations or delivery systems intended to discourage the abuse of CONTROLLED SUBSTANCES. These may include physical barriers to prevent chewing or crushing the drug; chemical barriers that prevent extraction of psychoactive ingredients; agonist-antagonist combinations to reduce euphoria associated with abuse; aversion, where controlled substances are combined with others that will produce an unpleasant effect if the patient manipulates the dosage form or exceeds the recommended dose; delivery systems that are resistant to abuse such as implants; or combinations of these methods.

**Tree numbers:** - D26.255.075 - D27.505.696.034 - D27.505.696.663.850.007 - D27.505.954.427.005 - E02.319.300.127 - E05.916.250.500

**Synonyms:** - Abuse-Deterrent Formulation